Atopic dermatitis pathophysiology and therapeutic targeting of the aryl hydrocarbon receptor: Lessons learned from keratinocytes, inflammatory cytokines and microbiota

Gijs Rikken

doi:10.54195/9789465150673

Atopic dermatitis pathophysiology and therapeutic targeting of the aryl hydrocarbon receptor: Lessons learned from keratinocytes, inflammatory cytokines and microbiota

Authors

Gijs Rikken

DOI: https://doi.org/10.54195/9789465150673

Keywords:

Organotypic human skin models, Inflammatory Skin Diseases, Skin microbiome, Therapeutics, The aryl hydrocarbon receptor, Epidermal structure and barrier function

Synopsis

The general aim of my thesis was to investigate the disease mechanisms by which epidermal keratinocytes drive or contribute to AD pathology by exploring interactions between keratinocytes, immune mediators and microbiota and how these can be targeted by therapeutics in preclinical organotypic skin models.

The following key objectives were defined to meet my thesis aim:
1. To develop organotypic epidermal equivalents to study inflammatory skin diseases.
2. To study the therapeutic spectrum and disease-modulating effects of aryl hydrocarbon receptor ligands.
3. To investigate host-microbe interactions important for skin health and in disease.