Real-world evidence in pediatric psoriasis: Moving towards non-invasive biomarkers and personalized care

Psoriasis is a chronic, immune-mediated inflammatory skin disease that develops during childhood in approximately one-third of patients. Beyond its physical symptoms, pediatric psoriasis can significantly impact quality of life and may be associated with systemic comorbidities. Effective disease management requires a personalized approach, considering disease severity, comorbidities, and patient preferences. This thesis aims to contribute to personalized treatment strategies by identifying potential biomarkers for disease severity and optimizing treatment approaches for pediatric psoriasis. The first part explores non-invasive biomarkers, including the use of the Transdermal Analysis Patch (TAP) for skin protein analysis, and investigates nail psoriasis as a potential predictor of a more severe disease course. The second part focuses on optimizing clinical management by evaluating real-world treatment patterns, the relationship between disease severity improvement and quality of life, and the effectiveness and safety of methotrexate.