The Tree of Biologics: Branching out into the Future of Psoriasis Treatment

Psoriasis is a chronic skin condition that can significantly impact a patient's quality of life. When biologics were developed as a treatment for psoriasis, there was already a solid foundation of other treatment options. Over the past 20 years, the "tree" of treatment options, including various biologics, has grown further. During this time, we’ve gained many insights, but some questions remain unanswered. For instance: What is the most effective biologic? And which biologic is best suited for which patient? Using data collected at Radboud university medical center and 23 other hospitals, we investigated these questions. Some key findings include that biologics from specific treatment classes achieved excellent results linked to their mechanisms of action. Additionally, we found that biologics were effective for both older adults and children. Lastly, the research methods we used offer directions for future studies.